Project: “Metabolic therapy of heart failure: which role for B vitamins”

Acronym	HF-MetaB (Reference Number: JTC-2019_055)
Duration	01/05/2020 - 30/04/2023
Project Topic	Heart failure (HF) is a major cause of death worldwide. Profound modulations of energy metabolism are involved in the development of HF, such as a drop in the cardiac levels of energy carrier compounds (ATP, Phosphocreatine (PCr)) and nicotinamide adenine dinucleotide (NAD+), a major coenzyme in energy generatione. In a previous mouse model of cardiac pressure overload, we were able to show the protective effect of diet supplementation of two vitamins, B12 and B9, stimulating the mitochondrial biogenesis pathways, or with nicotinamide riboside (NR), a recently characterized vitamin B3 which is a NAD+ precursor. Inasmuch as these treatments were given before the appearance of the first symptoms of HF in previous studies, we propose here to test the curative effect of a cocktail of these 3 B vitamins in symptomatic HF in mice. In a translational perspective toward clinics, we will also assess the impact of this vitamins cocktail in the context of standard medical HF care (β-blocker, ACE inhibitor). Finally, it is critically important to consider the sex differences in treatment of HF. Therefore our second aim is to compare the effect of the treatment between males and females that may differ according to the mitochondrial alterations in HF.
Network	ERA-CVD
Call	ERA-CVD Joint Transnational Call 2019

Number	Name	Role	Country
1	Paris Sud University	Coordinator	France
2	Université de Montréal	Partner	Canada
3	Slovak Academy of Sciences	Partner	Slovakia
4	Medical University of Vienna	Partner	Austria