Project: Adaptive Immune Responses in the wounded heart: novel diagnostic and therapeutic opportunities

Acronym	AIR-MI
Duration	01/05/2019 - 30/04/2021
Project Topic	Myocardial infarction and ensuing ischemic heart disease cause tremendous suffering and economic damage. Despite major advances in their treatment, molecular repair processes in the injured heart remain poorly understood. Consequently, we often cannot identify patients with inadequate repair before heart function deteriorates to a critical stage. Here, we propose that inflammatory processes, particularly T-cell mediated adaptive immune responses, critically regulate early cardiac repair. In our consortium, we will thus dissect T-cell responses in patients suffering from myocardial infarction using cutting-edge technologies such as next generation sequencing and correlate them with clinical outcomes. Further, we will integrate the results with data derived from mechanistic preclinical disease models investigating the role of adaptive immunity in myocardial infarction healing. These experiments will lay the fundament for developing novel immune-based prognostic tools and innovative treatment concepts in patients suffering from myocardial infarction and ischemic heart disease.
Network	ERA-CVD
Call	Joint Transnational Call for Proposal 2018 (JTC 2018)

Number	Name	Role	Country
1	Medical University of Graz	Coordinator	Austria
2	Sorbonne Université,	Partner	France
3	University Hospital of Würzburg	Partner	Germany