Project: Trained iMmunity in bonE MarrOw progenitors as dRiver of atherosclerosis in obesitY

Acronym	MEMORY
Duration	01/05/2019 - 30/04/2021
Project Topic	Due to the worldwide adoption of Western lifestyle, the prevalence of obesity increases exponentially. Obesity is an important risk factor for atherosclerotic cardiovascular disease, including heart attacks and strokes. The ultimate aim of this proposal is to understand how Western type diet and obesity induce atherosclerosis. We focus on the innate immune system, since this importantly contributes to atherosclerosis and we have recently shown that substances that can induce cardiovascular disease (such as cholesterol particles) can lead to a long-term activation of the innate immune system. We propose that Western type diet and obesity changes the development of the innate immune system in the bone marrow in such a way that they are prone to stimulate the development of atherosclerosis. Our results potentially can reveal novel mechanism that contribute to cardiovascular disease in subjects with obesity that can be used to develop novel drugs to prevent these diseases
Network	ERA-CVD
Call	Joint Transnational Call for Proposal 2018 (JTC 2018)

Number	Name	Role	Country
1	Radboud University Medical Center	Coordinator	Netherlands
2	University of Bonn	Partner	Germany
3	St-Antoine Hospital and Inserm	Partner	France