Project: Personalized Medicine in Infections: from Systems Biomedicine and Immunometabolism to Precision Diagnosis and Stratification Permitting Individualized Therapies

Acronym	PERMIT (Reference Number: ERAPERMED2018-151)
Duration	01/03/2019 - 28/02/2022
Project Topic	The PERMIT project proposes to implement personalised medicine in severe infectious diseases, specifically focusing on the rapidly progressing life-threatening necrotizing soft tissue infections (NSTI) as well as the large heterogeneous group of sepsis patients that represent a global health priority. PERMIT builds on the advances and resources created in the FP7-project INFECT, including the world’s largest patient cohort on NSTI, with an associated biobank and multi-omics data (transcriptomics and metabolomics). With this strong foundation, we can advance directly to the phase of preclinical validation of disease signatures/biomarkers and their underlying mechanisms, and the results can be translated into precision diagnosis enabling patient stratification for individualised therapy. One hypothesis to be explored is that immunometabolic processes are dysregulated and contribute to disease and as such, represent targets for tailored therapy. Specific aims are to: 1) identify disease signatures, through dissection of multiomics data, and delineate their underlying mechanisms, 2) engineering of customized organotypic tissue models for validation and intervention studies, 3) validation of identified signatures/biomarkers for patient classification by use of large patient cohorts, 4) development of novel concepts and stratification schemes for adjunctive therapy, 5) exploratory clinical studies of the new trial concepts, 6) data integration and 7) development of rapid decision support tools. Taken together, the activities proposed will demonstrate the clinical feasibility and advantages of personalised medicine in acute infectious diseases. Importantly, the advances are likely to benefit patient outcome through improved diagnostics and therapeutic strategies. To achieve its objective, PERMIT builds on a transnational interdisciplinary consortium of clinicians, experimentalists, bioinformaticians and computational modellers.
Network	ERA PerMed
Call	1st Joint Transnational Call for Proposals (2018)

Project partner

Number	Name	Role	Country
1	Karolinska Institutet	Coordinator	Sweden
2	University Hospital of Copenhagen, Rigshospitalet	Partner	Denmark
3	Haukeland University Hospital	Partner	Norway
4	LifeGlimmer GmbH	Partner	Germany
5	Wageningen University	Partner	Netherlands
6	Rode Kruis Ziekenhuis (Red Cross Hospital)	Partner	Netherlands