Project: PersonAlisation of RelApse risk in autoimmune DISEase
| Acronym | PARADISE (Reference Number: ERAPERMED2022-032) |
| Duration | 03/04/2023 - 02/04/2026 |
| Project Topic | Autoimmune disease affects 10% of adults, most of whom are women, and two of the top five medications with the highest cost globally are used to maintain these recurring conditions in remission. These medications act by suppressing the immune system, leaving the patient exposed to severe infection and at risk of cancer. Affected individuals receive standard treatment regimens for long periods of time, even though, in some cases, the autoimmune response may no longer be detectable. The general requirement for these medications, and their side effects, has been raised as a key target for research by the PARADISE consortium patient groups. Therefore, we aim to develop and validate a deployable personalised predictive tool that will accurately define the individual’s degree of immune system activation so that the medication dose can be tailored and, in some cases, stopped safely. We use systemic vasculitis as an archetypal autoimmune disease, integrating clinical, innovative biomarker and smartphone app-derived patient wellbeing data through a novel semantic web platform to inform predictive algorithms that will underpin a physician-facing tool. Such artificial intelligence (AI) applications are coming under intense scrutiny in the EU, so we will co-develop an “AI transparency notice” with the patient arm of the European Reference Network for immune disorders through a series of multi-stakeholder workshops, which will make explicit and explainable the full provenance of the PARADISE tool clinical outputs. |
| Network | ERA PerMed |
| Call | 5th Joint Transnational Call for Proposals (2022) |
Project partner
| Number | Name | Role | Country |
|---|---|---|---|
| 1 | The Provost, Fellows, Foundation Scholars and the other members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin | Coordinator | Ireland |
| 2 | Catholic University of Croatia | Partner | Croatia |
| 3 | KTH | Partner | Sweden |
| 4 | University of Freiburg | Partner | Germany |
| 5 | FIRALIS S.A. | Partner | France |
| 6 | The European Institute for Innovation Through Health Data AISBL | Partner | Belgium |
| 7 | Vasculitis Ireland Awareness | Partner | Ireland |
| 8 | Bellvitge Biomedical Research Institute | Partner | Spain |