Project: Towards Personalised Clinical Management of Suicide Risk through Data-Driven Clinical Decision Support using Transnational Electronic Registry Data.

Acronym	PERMANENS (Reference Number: ERAPERMED2022-091)
Duration	01/03/2023 - 28/02/2026
Project Topic	Two longstanding limitations hamper effective suicide risk management in clinical practice. First, unassisted clinical judgement is not sufficient to accurately assess suicide risk, leading to ineffective clinical decision-making and poor patient experience; and second, the need for adequate mental health treatment is often unmet among patients with suicide risk, and evidence indicates that adverse healthcare trajectories are associated with high morbidity, premature mortality and societal costs related to self-harm. The PERMANENS project aims to improve suicide prevention by developing a personalised Clinical Decision Support System [CDSS];, i.e., a medical software programme that assists in the personalised clinical evaluation and management of suicide risk. The CDSS will innovate current clinical practice by (1) increasing the prediction accuracy of suicide risk assessment; (2) enabling risk assessment for inadequate treatment delivery among patients with suicide risk; (3) enabling fine-grained clinical risk stratification; and (4) enabling the personalised matching of the identified risk profiles with effective treatment in order to improve indicated and tailored treatment trajectories among patients with suicide risk. Data for the project will be obtained from population-representative electronic registries from Ireland, Norway, Sweden, and Catalonia (Spain). Machine learning techniques will be used to develop accurate and clinically useful prediction models for suicide and adverse healthcare trajectories, including the identification of most important risk factors. Through co-creation and user-oriented qualitative implementation research with patients and clinicians, a user-friendly personalised CDSS prototype will be developed. The CDSS will be provided with a computerised clinical knowledge base on effective suicide prevention interventions and with a transferable personal healthcare record, fully acknowledging patients as end-users of their data.
Network	ERA PerMed
Call	5th Joint Transnational Call for Proposals (2022)

Project partner

Number	Name	Role	Country
1	Fundació Institut Hospital del Mar d'Investigacions Mèdiques	Coordinator	Spain
2	University of Oslo	Partner	Norway
3	Universitat Pompeu Fabra	Partner	Spain
4	Suicide Research Foundation CLG	Partner	Ireland
5	Karolinska Institutet	Partner	Sweden