Project: Personalised diagnosis and treatment for refractory focal paediatric and adult epilepsy

Acronym	PerEpi (Reference Number: ERAPERMED2020-227)
Project Topic	Epilepsy is among the most common neurological diseases, affecting between 0.5% and 1% of the general population. Therefore, new diagnosis and treatment methods have a high impact on society. Epilepsy is also among the most frequently diagnosed neurological paediatric disorders, with long-term implications for the quality of life of those affected. Only in two-thirds of cases, seizures can be adequately controlled with anticonvulsant drug treatment. For the remaining drug-refractory patients with focal epilepsy (up to about 2 Mill. in Europe), epilepsy surgery is currently the most effective treatment. However, only 15-20% of those patients are eligible for epilepsy surgery. That is either because the epileptogenic zone in the brain cannot be localized with sufficient accuracy with standard diagnostic means, or because the epileptogenic zone overlaps with eloquent cortical areas, so that it cannot be surgically removed without considerable neurological deficit. PerEpi aims to bring together a group of experts at the European level to improve this situation in two ways, both of which use concepts of non-invasive personalised medicine: The first one focuses on a new individualised multimodal approach to set a new milestone in localization accuracy of the epileptogenic zone in order to offer the most appropriate personalised therapy. The second one focuses on a new individually optimized transcranial electric brain stimulation technique as a new treatment option to reduce seizure frequency and severity. This is particularly attractive for those focal refractory patients where surgery is not an option because of an overlap with eloquent cortical areas. A dedicated ethics work package will ensure that the research in the consortium is designed and conducted following the highest ethical standards. In addition, this work package will study the translational pathways of the new approaches to foster clinical integration that is ethically and socially responsible.
Network	ERA PerMed
Call	3rd Joint Transnational Call for Proposals (2020)

Project partner

Number	Name	Role	Country
1	Westfälische Wilhelms-Universität Münster	Coordinator	Germany
2	Universite de Picardie Jules Verne	Partner	France
3	Tampere University	Partner	Finland
4	Technical University Munich	Partner	Germany