Project: Multi-dimensional stratification of Parkinson’s disease patients for personalised interventions.

Acronym	PD-Strat (Reference Number: JTC2_11)
Duration	01/07/2018 - 31/03/2022
Project Topic	Parkinson’s Disease (PD) is a highly prevalent disabling and progressive neurological disease, with more than 800,000 affected people in theEU, which causes an increasing personal, societal and financial burden. Although symptomatic treatment has been successful, no therapyexists that halts or slows down the neurodegenerative process. We hypothesise that clinical trials have consistently failed for three mainreasons. First, selection of potential drug targets is rarely based on convincing biological evidence. Second, the disease process beginsdecades before clinical symptoms are observed and clinical trials on patients are therefore likely too late to reverse the neurodegeneration.Third, participants have been selected largely ignoring their underlying disease biology, phenotypic variation and their genetic risk profile,resulting in a very heterogeneous population of cases with very different progression of disease.Therefore we aim to develop a novel concept for disease-mechanism based disease onset and progression prediction and subsequenttarget discovery and patient stratification for Parkinson’s disease. Our goals are to generate novel targets based on biological evidence withmatching precision cohorts for clinical trials that will allow for personalised therapeutic interventions based on genetic and genomic riskprofiles and clinical subtypes.To reach our goal, we will use a systems biology approach by generating multi-dimensional clinical, genetic/genomic and biological risk andprogression profiles for our patients and at risk individuals and integrate these data in gene expression models for target discovery anddisease prediction and progression models for patient stratification.Our project is distinguished by linking up investigators and research centres across Europe with substantial experience in genetics,genomics, and fundamental basic science, computational analysis and in the development of clinical trials.
Network	ERACoSysMed
Call	2nd Joint Transnational Call for European Research Projects on Systems Medicine

Project partner

Number	Name	Role	Country
1	German Center for Neurodegenerative Diseases	Coordinator	Germany
2	Eberhard-Karls-University Tuebingen	Partner	Germany
3	University of Luxembourg	Partner	Luxembourg
4	INSERM UMRS 1127, ICM, Clinical Research Center for Neurosciences, Pitié-Salpêtrière Hospital	Partner	France