Project: Ion-release materials to promote angiogenesis on dermal regeneration

Acronym	nAngioDerm (Reference Number: JTC2018-103)
Duration	01/06/2019 - 31/12/2022
Project Topic	nAngioDerm will develop nanostructured ion-release platforms and devices that promote the in situ regeneration of damaged skin without the need of cells or growth factors. nAngioDerm’s innovative approach is based on the controlled release of bioactive ions (Zn2+, Ag+, Ca2+) from biodegradable polymeric nanocarriers, which will be developed using a nano-precipitation technique. These bioactive ions will promote cell recruitment and colonization and provide an antibacterial effect, as well as triggering the synthesis of angiogenic factors and extracellular matrix components that will facilitate wound healing. Depending on the type of skin injury, the ion-releasing nanocarriers will be: 1) combined with 3D printed collagen-based scaffolds as filling and guiding biomaterials for chronic wounds such as diabetic or pressure ulcers; or 2) dispersed in a spray based on a thermos-responsive collagen gel for acute wounds related to burns. The devices and platforms proposed here will be assessed in vitro and in suitable preclinical in vivo models as per EMA guidelines, bringing them to technology readiness level 4-5, close to clinical translation and market transferability stages. The comprehensive nAngioDerm project will equip recruited researchers with a transferable and multidisciplinary skill set to enable them to adapt quickly to the challenging needs of the medtech sector and affording them rapid ascent to key leadership positions in the field. In the long-term, the technologies developed will be implemented in other clinical areas, resulting in increased European-based knowledge, innovation, competitiveness and leadership in the field.
Website	visit project website
Network	EuroNanoMed III
Call	Joint Transnational Call (2018)

Project partner

Number	Name	Role	Country
1	Institute for Bioenginnering of Catalonia	Coordinator	Spain
2	University of Ioannina	Partner	Greece
3	Hospital Universitario Vall d'Hebrón	Partner	Spain
4	Universitè Grenoble Alpes	Partner	France
5	Microlight SAS	Partner	France