Project: Nano-delivery system for one-shot regenerative therapy of peri-implantitis

Acronym	ImplantNano (Reference Number: EURONANOMED2019-118)
Duration	01/01/2020 - 31/12/2022
Project Topic	Dental implants are prevailing treatment solution for tooth replacement in the current restorative dentistry. However, peri-implant infection is highly prevalent complication of dental implants due to permanent exposure to the infective threats. Moreover, peri-implantitis was qualified important pathological entity due to lack of standard treatment protocol. The insufficient implant surface decontamination was proposed the main culprit for that, supported by the findings that repeated antibiotic use substantially improves treatment outcomes. Hence, this research team invented nano-drug delivery system composed of nano-hydroxyapatite (nHa) with antibiotic (AB) incorporated in PLGLA for simultaneous bone regeneration (BR) and controlled AB release during critical period of bone healing in one-shot manner (nHaAB). The antimicrobial regimen was designed against peri-implantitis key-stone pathogen, while the effects were estimated using histological techniques, pharmacokinetic and personalized approach to assess biochemical markers using Luminex® and the pathogen using RT-PCR. Outcomes of this double-controlled study in dog showed that experimental material was the single to significantly reduce infection/inflammation following treatment, while the pharmacokinetic properties suggested safety of the device regarding risk for antimicrobial resistance. Finally, two implications for future research raised from the study: 1) Use of Ti-adhesive hydrogels/membrane would enable better stabilization of the fine nano particles thus contributing to better BR 2) Use of non-AB antimicrobial under established regimen might provide comparable outcomes. Thus, the objectives of the present project are to compare the antimicrobial properties of nHaAB and novel nHa conjugated with Ga3+ ions, and to estimate whether use of Ti-adhesive hydrogels/membrane improves BR. The expected project outcome is ready-to use composite-nano drug delivery systems for one-shot treatment of peri-implantitis.
Network	EuroNanoMed III
Call	Joint Transnational Call (2019)

Project partner

Number	Name	Role	Country
1	Riga Technical University - RTU	Coordinator	Latvia
2	Nantes University/Inserm	Partner	France
3	Laval University	Partner	Canada
4	HTL Biotechnology	Partner	France