Project: BIOMIMETIC PLATELET-DERIVED NANOMEDICINES FOR TREATMENT OF THROMBOEMBOLIC STROKE
| Acronym | PLATMED (Reference Number: EURONANOMED2020-143) |
| Duration | 01/01/2021 - 01/01/2024 |
| Project Topic | Thrombolysis with intravenous recombinant tissue plasminogen activator (rtPA) is the only approved drug treatment for patients with acute ischemic stroke, but its use is limited by a narrow therapeutic window, selective efficacy, and haemorrhagic complications. Nanotechnology has emerged as a promising strategy to improve the efficacy and safety of rtPA and for ischemia diagnosis. In line with the main scope of the EuroNanoMed call, Diagnostics and Targeted delivery systems, the PLATMED project expects to develop biomimetic-platelet nanocarriers loaded with rtPA that, potentially, will remain “invisible” to the phagocytic system, thereby increasing their free-life in blood circulation and improving the targeting efficiency toward blood-clots. These nanostructures will be sonosensitive; that is, rtPA will be released by external ultrasound irradiation (non-invasive) in the cerebral ischemic region. In addition, the inclusion of contrast agents in the nanocarrier will allow to follow artery recanalization by means of non-invasive imaging methodologies such as MRI/PET. The main ambition of the PLATMED project is to fabricate a new model of “smart” nanomedicines in order to improve the thrombolytic efficacy of rtPA, reduce the risk of systemic bleeding and haemorrhage, and evaluate the recanalization rate by imaging techniques. This innovative strategy is expected to improve the outcome of rtPA-treated stroke patients, increase the therapeutic time-window, and thus the number of stroke patients that can benefit from this treatment. |
| Network | EuroNanoMed III |
| Call | Joint Transnational Call (2020) |
Project partner
| Number | Name | Role | Country |
|---|---|---|---|
| 1 | Health Research Institute of Santiago de Compostela (IDIS) // Clinical University Hospital (CHUS) | Coordinator | Spain |
| 2 | University of Santiago de Compostela (USC) | Partner | Spain |
| 3 | University Caen-Normandy, GIP Cyceron | Partner | France |
| 4 | McGill University | Partner | Canada |
| 5 | Op2Lysis | Partner | France |