Project: 3D co-cultures of human PC and NPC cells from same liver: Prediction of Drug-induced liver injury
| Acronym | CRYOSPHERE (Reference Number: 11034) |
| Duration | 01/03/2017 |
| Project Topic | The project aims to develop and commercialize novel 3D spheroid-co-cultures of human hepatocytes and liver non-parenchymal cells from the same human liver donors including: - 3D spheroid co-cultures (to predict drug metabolism and hepatotoxicity); - Pharmacogenetic profiles of donors for studying inter-individual genetic variation; - Cryopreservation methods for spheroids; - New models to analyse drug hepatotoxicity in diseased livers (steatosis, fibrosis, cholestasis) and validate new drugs. |
| Network | Eurostars 2 |
| Call | Eurostars Cut-Off 6 |
Project partner
| Number | Name | Role | Country |
|---|---|---|---|
| 1 | KaLy-Cell | Coordinator | France |
| 2 | Karolinska Institutet | Partner | Sweden |