Project: Innovating GPCR Drug Discovery with Protein Engineering and Biophysics

We will develop powerful methods to generate new medicines targeting G-protein coupled receptors, which are important drug targets. We will utilize the CHESS technology of UZH where large quantities of stable, functional GPCRs are produced in E. coli. ZoBio will develop methods to 1) find drug fragments that bind the stabilized receptors at a selected site and elicit a desired response and 2) rapidly determine where and how these fragments bind to the GPCR using Nuclear Magnetic Resonance.

Acronym	EcoNMR (Reference Number: 8939)
Duration	01/10/2014 - 01/10/2017
Project Topic	Biological Sciences / Technologies
Network	Eurostars 2
Call	Eurostars Cut-Off 1

Project partner

Number	Name	Role	Country
18435	ZoBio	Coordinator	Netherlands
18436	University of Zurich	Partner	Switzerland