Project: Viral RNA-protein interaction on graphene-based field effect transistors as a new avenue for viral
| Acronym | G-Virals |
| Duration | 01/02/2024 - 31/01/2027 |
| Project Topic | Consequently, this remains a major challenge in the field. The GRAPH-OCD project seeks to address this challenge by developing a viscoelastic hydrogel utilizing a combination of SA and GO. Graphene oxide and its bioinspired derivatives will be incorporated into the hydrogel to enhance its mechanical properties, enabling it to closely resemble the extracellular matrix (ECM) and facilitate effective cell integration. Moreover, bioorthogonal chemistry will be employed to introduce non-covalent and covalent crosslinks for the preparation of the injectable scaffold. The biocompatibility of the hydrogel will be carefully ensured throughout this process. To the best of our knowledge, GO-based injectable hydrogels have not been tested in osteochondral repair. In summary, this innovative approach represents a significant advancement in the repair of both cartilage and subchondral bone, holding great promise for future developments in the field. To meet the fundamental requirements for successful osteochondral repair, the hydrogel composition will be carefully modulated within the GRAPH-OCD project. This modulation will address key aspects such as chondrogenesis promotion, bone formation, and biodegradation without toxic by-products. By optimizing these properties, the proposed GRAPH-OCD platform aims to provide an effective solution for osteochondral repair. The performance and efficacy of the developed hydrogel will be evaluated in a sheep model, serving as a representative animal model for osteochondral defect repair. These innovative strategies and materials are expected to pave the way for future advancements in cell-free scaffold constructs, bringing shear-thinning hydrogels one step closer to clinical application in the field of joint regenerative medicine. |
| Network | FLAG-ERA III |
| Call | Flag-ERA JTC 2023 |
Project partner
| Number | Name | Role | Country |
|---|---|---|---|
| IEMN - Institut d'Electronique, de Microélectronique et de Nanotechnologie | Coordinator | France | |
| Institut de biologie moléculaire des plantes (UPR 2357) | Partner | France | |
| UNIVERSITE PARIS CITE | Partner | France | |
| University of Regensburg | Partner | Germany | |
| Université catholique de Louvain | Partner | Belgium | |
| Centre for Adv. Materials Application | Partner | Slovakia |