Project: International Fungal Network for One-Health Resistance Surveillance: Antifungal Resistance

Acronym	INFORM-AFR (Reference Number: JPIAMR_NC_2022-012)
Project Topic	Antifungal resistance (AFR) is an increasing concern in fungal pathogens, including Aspergillusfumigatus, yeastsand uncommon moulds that may cause breakthrough infection. There are currently no international AFRsurveillance programs,aspublic health surveillance commonly focus on bacterial resistance. Acquired AFRmay develop through in host resistance selection and through exposure of fungi to fungicides in our environment, underscoring the requirement for a One Health approach to AFR surveillance. In this proposal we aim to provide a snap shot of current nationalAFRsurveillance initiatives through anonline survey, including identifyingthe stakeholders involved (deliverable 1). We subsequently willorganize a start-up workshop aimed to design surveillance programsthat involves clinical and environmental sampling, the use of genomics tools and data management. We aim to involve all relevant stakeholders, including public health institutes, mycology excellence centresand reference laboratories, and environmental and veterinary research groups. The outcome of this workshop will be a surveillance framework that enables systematic resistance surveillance in multiple countries, thus allowing inter-country comparisons (deliverable 2). To increase efficacy we aim to develop standardized surveillance for multiple fungal pathogens including A. fumigatus, yeastsand non-fumigatusmoulds (deliverable 3). Laboratory protocols(clinical and environmental), culture collections, case record forms, data management and exchange, privacy and ethical approval issues, and communication plans will be developed. Using this framework, we will apply for funding to secure support to perform surveillance and scientific research associated with the network (deliverable 4).
Website	visit project website
Network	JPIAMR-ACTION
Call	3rd JPIAMR-ACTION Joint Call 2022

Project partner

Number	Name	Role	Country
1	Radboud University Medical Center	Coordinator	Netherlands
2	PHW Mycology Reference Laboratory	Observer	United Kingdom
3	Imperial College School of Public Health	Observer	United Kingdom
4	UK Health Security Agency	Observer	United Kingdom
5	Manchester University Foundation Trust, Wythenshawe Hospital	Observer	United Kingdom
6	Institut Pasteur	Observer	France
7	Université Paris Cité	Observer	France
8	University of Rennes	Observer	France
9	University Hospital of Besançon	Observer	France
10	University Hospital of Strasbourg	Observer	France
11	University Hospitals Leuven/ University of Leuven	Observer	Belgium
12	National Institute for Public Health and the Environment	Observer	Netherlands
13	Wageningen University & Research	Observer	Netherlands
14	Trinity College Dublin	Observer	Ireland
15	Children’s Health Ireland	Observer	Ireland
16	Norwegian Veterinary Institute	Observer	Norway
17	Oslo University Hospital	Observer	Norway
18	Instituto de Salud Carlos III	Observer	Spain
19	Instituto de Salud Carlos III	Observer	Spain
20	Institut of Hygiene and Medical Microbiology	Observer	Austria
21	Medical University of Graz	Observer	Austria
22	Attikon University General Hospital, Medical School, National and Kapodistrian University of Athens	Observer	Greece
23	Vallabhbhai Patel Chest Institute, University of Delhi	Observer	India
24	Centers for Disease Control and Prevention	Observer	United States
25	Alfred Health	Observer	Australia
26	SA Pathology	Observer	Australia
27	Africa Centers for Disease Control and Prevention	Observer	Ethiopia
28	Julius-Maximilians-University of Wuerzburg	Observer	Germany
29	University of Cologne	Observer	Germany
30	Statens Serum Institut	Observer	Denmark