Project: Cellular Bioenergetics in Neurodegenerative Diseases: A system-based pathway and target analysis
We aim to apply a systems-based analysis to determine the contribution of mitochondria and cell bioenergetics to pathological processes in the most common forms of neurodegenerative disorders. We will use two complementary approaches: 1) Quantitative, standardised temporal and spatial analysis of alterations in bioenergetics and in signalling pathways regulating bioenergetics in relation to pathological features and symptoms in experimental models of Parkinson’s disease (PD), compared to models of Alzheimer’s disease (AD) and Huntington’s disease (HD). To better recapitulate disease phenotypes including mitochondrial dysfunctions these genetically modified cells or animals will be exposed to a ‘second hit’: hyperexcitability/Ca2+ overloading or metabolic stress. From this we will develop computational models for mitochondrial respiration, metabolic flux and AMPK signalling. 2) In a parallel approach, we will perform a High-through put screen (HTS) of drugs enhancing mitochondrial functions and showing neuroprotection. HTS will further be employed to refine computational models. New therapeutic strategies will be subsequently tested in cellular and animal models available in the partner’s laboratories. The Cellular Bioenergetics in Neurodegenerative Diseases (CeBioN) consortium will provide un-precedented insights into the contribution of mitochondria and cell bioenergetics to neurodegeneration in AD, PD and HD and will identify novel therapeutic strategies.
| Acronym | CeBioN (Reference Number: JPND_CD_FP-688-025) |
| Duration | 01/01/2015 - 01/01/2018 |
| Project Topic | Neurodegenerative disease |
| Website | visit project website |
| Network | JPND |
| Call | A call for European research projects for cross-disease analysis of pathways related to neurodegenerative diseases |
Project partner
| Number | Name | Role | Country |
|---|---|---|---|
| 1 | Karolinska Institutet | Coordinator | Sweden |
| 2 | Royal College of Surgeons in Ireland | Partner | Ireland |
| 3 | University of Padua | Partner | Italy |
| 4 | University of Ottawa | Partner | Canada |
| 5 | German Center for Neurodegenerative Diseases (DZNE) | Partner | Germany |