Project: COnsequences of Haemostatic Defects after IntraCerebral Haemorrhage

Acronym	COHDICH (Reference Number: NEURON_CV-041)
Project Topic	Cerebral microhaemorrhages (CMHs) are predictors of future intracerebral haemorrhage (ICH). While CMHs are mainly seen as markers of the underlying vessel disease, to what extent haemostatic disorders influence CMH incidence and transformation into ICH remains unclear. Congenital haemostatic defects are unique situations, in which ICH is frequent and devastating. Hypothesis: In the setting of CMHs, the existence of a haemostatic disorder promotes macrobleeding, and modulates the inflammatory response around the bleeding when a macrobleeding occurs. COHDICH offers a translational approach from animal models with severe haemostatic defects to patients with cerebral bleedings. In workpackage 1, we will: (i) determine the prevalence of CMHs in patients with severe haemostatic defects related to the coagulation cascade (haemophilia) or primary haemostasis (von Willebrand disease, vWD), and (ii) evaluate the influence of impaired haemostasis on the inflammatory response around ICH. In workpackage 2, we will induce CMHs in mouse models for haemophilia and VWD, and explore their transformation into ICHs. In addition, we will study the role of these haemostatic defects in perspective of the inflammatory response around the bleeding. Relevance to public health: Identifying predictors of future cerebral bleedings is of utmost importance and may lead to a change in patients’ preventive treatment regimen. COHDICH fills a knowledge gap and could pave the way to new treatments.
Network	NEURON Cofund2
Call	Neuron Cofund2 Joint Call 2022

Project partner

Number	Name	Role	Country
1	Department of Neurology and stroke centre	Coordinator	France
2	U1176	Partner	France
3	Center for Stroke Research Berlin	Partner	Germany
4	Neurology	Partner	Taiwan